The efficacy and effectiveness of early orthodontic and orthopedic treatment is examined. An overview of evidence-based clinical studies, including randomized clinical trials and retrospective investigations, is presented by a number of international investigators, including Proffit, Pancherz, Graber, Wheeler, Turley, Johnston, Baccetti, Franchi, O'Brien, Mills, Lamparski, and Bowman. Published in 2002.

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